CYP2C19 Polymorphisms and Antiplatelet Effects of Clopidogrel in Acute Ischemic Stroke in China
نویسندگان
چکیده
منابع مشابه
CYP2C19 polymorphisms and antiplatelet effects of clopidogrel in acute ischemic stroke in China.
BACKGROUND AND PURPOSE Little research regarding genotypes and clopidogrel response related to acute ischemic stroke has been published. This study was conducted to investigate whether the polymorphisms of receptors or enzymes involved in the metabolic process of clopidogrel affect clopidogrel response and prognosis related to acute stroke. METHODS A total of 259 patients with acute ischemic ...
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background: clopidogrel is one of the most commonly prescribed drugs to prevent ischemic events following coronary syndromes or stent placement. however, impaired responses to therapy as well as resistance are also reported. genetic variants play an important role in clopidogrel biotransformation to its active metabolite that may subsequently influence the clopidogrel antiplatelet effect. the o...
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Aim. The aim of this study was to evaluate the complex effects of polymorphisms of the gene encoding the CYP2C19 enzyme on the antiplatelet efficacy of clopidogrel during follow-up visits. Material and methods. This study was designed as a prospective, single-centre observational clinical trial with a one-year follow-up. Data from 178 patients on clopidogrel, taken during follow-up visits, was ...
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The CY2C19 and P2Y12 gene polymorphisms are responsible for resistance to clopidogrel, known as drug unresponsiveness. In this study we researched the effect of gene polymorphism on clinical results of patients who began clopidogrel therapy after acute ischemic cerebrovascular disease. The study included 51 patients. The patient group included patients who had begun prophylactic clopidogrel due...
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ژورنال
عنوان ژورنال: Stroke
سال: 2013
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.113.000823